Can mammalian vision be restored following optic nerve degeneration?
نویسندگان
چکیده
منابع مشابه
Optic Nerve Degeneration and Ageing
Major pathological hallmarks of Alzheimer Disease are insoluble deposits of the short amyloid β-peptide (β-amyloid, Aβ), which is derived by sequential proteolytic cleavage from a large type I trans-membrane protein, the β-amyloid precursor protein (APP). APP is anterogradely transported by fast axonal transport in a distinct transport vesicle, but both the biochemical composition of such a ves...
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We cut the optic nerve at the orbital apex in squirrel monkeys to study the descending degeneration of optic nerve axons and their ganglion cell bodies. We could not detect progressive disintegration of the axon from the site of injury back to the cell body. Instead, the entire length of individual axons seemed to degenerate simultaneously as early as 3 weeks and as late as 6 weeks after injury...
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Purpose To assess the therapeutic potential of edaravone, a free radical scavenger that is used for the treatment of acute brain infarction and amyotrophic lateral sclerosis, in a mouse model of optic nerve injury (ONI). Methods Two microliters of edaravone (7.2 mM) or vehicle were injected intraocularly 3 minutes after ONI. Optical coherence tomography, retrograde labeling of retinal ganglio...
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ژورنال
عنوان ژورنال: Journal of Neurorestoratology
سال: 2016
ISSN: 2324-2426
DOI: 10.2147/jn.s109523